Ihre Spezialisten bei unerfüllter Kinderlosigkeit und Kinderwunsch für Berlin und Brandenburg

Dr. med. Reinhard Hannen

Dr. med. Christian Stoll

Landgrafenstr. 14
10787 Berlin/ Tiergarten


Tel.: +49.(0)30.263 983 - 0
Fax: +49.(0)30.263 983 - 99
Montag, Mittwoch, Freitag: 8.00-12.00, 14.00-18.00 Uhr
Dienstag, Donnerstag: 8.00-12.00 Uhr

Wir bitten Sie nach Möglichkeit um eine Terminvereinbarung.

Kinderwunsch Zentrum Kinderwunschzentrum Berlin und Brandenburg bei unerflltem Kinderwunsch

Treatment Methods for Undesired Childlessness


The causes of undesired childlessness are individual, therefore there are many forms of therapy.

In our fertility centre we offer all types of therapy in accordance with the most up-to-date scientific developments. Working together with you, we always select a form of therapy which is tailored to your personal needs.

We do not only rely upon medical recommendations here but also take your wishes into consideration. The various methods will now be presented individually:

Optimisation of Cycle

Here, the natural cycle is observed through both ultrasound and the level of hormones in the blood (in some cases hormones are administered). At the right point in time, ovulation is set into motion and the couple is advised to have intercourse at the optimum moment.

Hormone Therapy

During a natural cycle, the woman normally develops one follicle. As not every egg cell is fertilised and on average only every tenth fertilised egg cell develops into an intact pregnancy, the probability of successful in-vitro fertilisation during an untreated natural menstrual cycle (that means without first stimulating the ovaries) is low (around 5%). In order to increases the chances of pregnancy, IVF and ICSI and, often, insemination are generally carried out after having first stimulated the ovaries.

Here you can see various stimulation scenarios:


Simmulation beu unerfülltem Kinderwunsch(enlarge)


Stimmulation bei unerfülltem Kinderwunsch(enlarge)


Stimmulation bei unerfülltem Kinderwunsch(enlarge)


The aim of this procedure is to increase the number of mature follicles, to improve the quality and potential for development of the egg cells and to control the maturing of the follicle and ovulation. The main advantage of this ovarian stimulation treatment is the higher rate of pregnancy per attempted treatment, according to the type of treatment (IVF, insemination) and natural factors (age, sperm quality). An intro-uterine insemination treatment is not very effective as an isolated method. In a spontaneous, untreated cycle, pregnancy rates of just 3% are reported following insemination. After a hormonal stimulation of the ovaries, the pregnancy rate of an intro-uterine insemination lies at around 10% to 15% per attempt.

Insemination (heterologic and homologic)

If the quality of the semen is insufficient, then a special treatment which filters out the best sperm can make sense. This can then be released into the uterus at the moment of ovulation with the aid of a plastic tube. The aim of this method is to increase the number of fertile sperm in the woman’s fallopian tube, in order to increase the likelihood of successful fertilisation. This procedure is completely painless and can greatly increase the probability of becoming pregnant. Intra-uterine insemination is used when the quality of the sperm is slightly lower than required.

Insemination bei unerfüllter Kinderwunsch(enlarge)

In Vitro Fertilisation

If, for example, both fallopian tubes are blocked, then fertilisation of the egg cell has to take place outside the body. These methods are called In Vitro Fertilisation (IVF) because the fertilisation of the egg cell takes place in a petri dish. First, the egg cells are gathered.

In Vitro Fertilisation InVitroFertilisation im Kinderwunschzentrum(enlarge)

The suction of the follicles takes place with the aid of ultrasound during a short general anesthetic here at our fertility clinic. The egg cells are extracted from the follicles using a fine needle which is inserted through the vaginal wall and are then brought together with the semen filaments in a test tube.


IVF Winschkind Kinderwunschzentrum(enlarge)

ICSI (Intro Cytoplasmatic Sperm Injection)

With the ICSI method, one individual sperm filament is inserted into each individual egg cell respectively, under a microscope and using a micro pipette. This method is often employed when sperm quality is extremely low.


ICSI Kinderwunsch Berlin Brandenburg(enlarge)

Here you can see the embryo transfer. Problems rarely occur and it is completely painless:

Embryotransfer Kinderwunschzentrum(enlarge)


Further methods that can increase the likelihood of becoming pregnant

As infertility treatment unfortunately does not guarantee certain pregnancy, doctors and biologists have long been working on procedures which increase the probability of becoming pregnant. If one exhausted the complete spectrum, then, in an ideal case, the rate of pregnancy could be increased by up to one third. In the Kinderwunschzentrum (Fertility Centre) Berlin, we offer you all the possibilities that are allowed in Germany and that have a proven positive influence on the probability of becoming pregnant. Amongst other methods, we offer:

Assisted Hatching

Various studies have shown that the creation of a small opening in the embryonic membrane of the egg (zona pellucida) just before the embryo transfer can improve hatching and thus, the implantation itself. Higher implantation and pregnancy rates have been recorded in older women and in women whose egg cells are encased in a particularly thick embryonic membrane.

Einnistung unerfüllter Kinderwunsch(enlarge)


Our centre has equipment which can create this small opening in the zona pellucida within seconds and without risk of damage to the embryo, using a fine laser beam.

Polar body examination

An assessment of the chromosome complement can be made through the removal of a polar body from the egg cell (polar body examination). As not every egg cell is genetically sound, healthy egg cells can hereby be selected and later transferred as embryos.

Spindel View

The spindle plays a central role in the maturing of the human egg cell; it is responsible for the careful alignment and distribution of the chromosomes during cell division. As women age, abnormalities in the spindle begin to occur. The absence of the spindle correlates to a significantly reduced fertilisation rate and a bad or non-existent development of the embryo. In addition, the alignment of the spindle during ICSI influences the further development of the embryo. The embryo only has the best chance of a successful pregnancy if the chromosome distribution is correct.

Extended Egg-cell Culture (Blasto-cyst Culture)

In blasto-cyst culture, the embryos are not transferred on the third day but on the fifth day. A blasto-cyst is an embryo which is further on in its development. Only 40% of all embryos ever reach the blasto-cyst stage. The extended egg cell culture improves the synchronization between the uterus, the endometrium and the embryo. The knowledge of the development potential of the embryo allows an assessment of the probability of the start of a pregnancy to be made.

Furthermore, higher implantation rates of embryos in the womb have been recorded. We offer blasto-cyst culture to couples who have already completed 2-3 unsuccessful IVF cycles, in order to gain information as to whether the embryonal genome is perhaps not activated and if the embryos remain in the 4-8 cell stage.

Sperm Selection using PICSI

PICSI is a medical product available to support the biologist in the selection of a suitable sperm. Here, the principle that the sperm naturally attaches to the hyaluronic acid of the egg cell complex is used.

On the basis of a study from the highly-regarded American Yale University, the binding behaviour of ejaculation samples from men were examined. The results of this work led to the conclusion that the certainty of finding a chromosomally intact sperm through use of a PICSI dish can be increased by a factor of 4.

Freezing of Egg Cells in the Pronucleus Stage

If more than two egg cells are fertilised during artificial insemination and should these be in the pronucleus stage, then they can be stored at –196°C in liquid nitrogen. The process of freezing and storing in a frozen state is called cryo- preservation.

At a later point in time, these egg cells can be thawed and transferred back into their womb (embryo transfer). This method allows the fertility team to transfer fewer embryos per cycle and thus to reduce the risk of a multiple pregnancy. At the same time, pregnancy can be achieved through the transfer of thawed egg cells (cryo cycle) should a pregnancy not occur or should the couple desire to have a further child. Treatment involving hormone injections is usually not necessary for the transfer of cryo preserved, thawed egg cells in the pronucleus stage. The endometrium is prepared for the embryo transfer through the administration of hormones in tablet form. The probability of a successful pregnancy is somewhat lower than in a stimulated treatment cycle.

Freezing of Egg-cells, Sperm, Testicle Material (TESE) or Ovarian Material

In the case of cancer, the survival of the patient is of utmost importance. Thanks to modern treatment methods such as operations, chemotherapy and radiotherapy, more and more patients are winning the fight against cancer. We offer the possibility of freezing and storing semen cells, egg cells, testicle tissue (TESE) or ovarian tissue in order to retain fertility, before starting chemotherapy or radiotherapy. The cryo preservation of these gametes requires complicated preparation. Therefore it is advisable, that the doctor in charge and the patient contact us as soon as the cancer diagnosis has been made. In such cases, advisory appointments are made immediately.

TSE Wunschkind(enlarge)


The „Implantation Injection“

There is proof that a special medicine can ease the implantation of the embryo in the womb. We call this injection the “implantation injection”.

Embryo „Glue“ to improve Embryo Implantation

A medium has existed since 2002, which was specially developed for the transfer of the embryo following artificial insemination and which is thought to improve nidation (implantation). Its physical properties are similar to the secretions in the womb and can help the embryo to implant itself into the endometrium.


Methods of Treatment




Kinderwunsch Zentrum Berlin: Wir erfllen Ihren Kinderwunsch im Kinderwunschzentrum fr Berlin Potsdam Brandenburg | Kinderwunschbehandlung, Kinderwunschklinik, Sterilitt, knstlicher Befruchtung, IVF, ICSI, Insemination, PCO, schwanger werden, Unfruchtbarkeit, Reproduktionsmedizin